Toxicology and Pharmacokinetic Studies

Overview:

Mice, rats, or guinea pigs are dosed with sponsor-provided experimental test compounds and evaluated for either acute or chronic toxicity. During the live phase of the study, animals are monitored for signs of toxicity and weighed daily. At the time of necropsy, a systematic gross examination of each animal’s general physical condition, body orifices, external and internal organs and tissues will occur. Sponsor-selected organs are collected, trimmed, and weighed. Organ weights are expressed as absolute, relative to body weight, and relative to brain weight.

Additionally, tissues can be examined microscopically by a board certified veterinary pathologist (Dr. Alison Bendele).

Dosing Paradigms:

  • Route of administration: SC, PO, IP, IV, IA, IR, ID, Ad libitum

Optional Endpoint

  • PK/PD blood collections
  • Cytokine/chemokine analysis via Luminex(R)
  • Other sandwich ELISAs
  • CBC/clinical chemistry analysis
  • Soft tissue collection
  • Histopathologic analysis
  • Immunohistochemistry analysis

Overview:

We regularly collect blood samples for PD/PK analysis, either as a stand alone study or as part of an efficacy experiment. Animals are then bled at sponsor-requested time points, typically via either the tail vein or retro-orbital routes for interim collections.

*We do not have the ability to analyze the blood collections for drug levels.

Dosing Paradigms:

  • Route of administration: PO, IV, SC, IP, IA, IR, IM, ID, Topical, Ad libitum

Optional Endpoint

  • Cytokine/chemokine analysis via Luminex(R)
  • Other sandwich ELISAs
  • CBC/clinical chemistry analysis
  • Soft tissue collection
  • Histopathologic analysis
  • Immunohistochemistry analysis


For more information about Toxicology and Pharmacokinetic Studies contact us here.

Tell Us About Your Project! Get a Quote »